Meso vs. RF Microneedling

As they get older, many people are looking for ways to rejuvenate their skin and relieve scars while making fine lines and wrinkles less visible. Numerous treatments are available, but someone who hasn’t researched each option in detail may not know which one to settle for.

Mesotherapy and microneedling are two popular procedures to treat signs of aging. Although they are both very effective, they are performed differently, and the needles used are different too. If you’re interested in any of these procedures, you may want to know what they involve and who they’re best for, so you can pick the right one. 

Let’s take a look at mesotherapy and microneedling in more detail so you can understand the procedures. 

What Is Mesotherapy?

Mesotherapy is a procedure that involves inserting needles into the mesodermal layer of the skin, injecting vitamins, hormones, enzymes, and various other substances into it. This helps rejuvenate the skin and make it feel tighter. Moreover, it has the power to get rid of additional fat. It’s minimally invasive, and it’s one of the reasons why people prefer it. 

It was developed in 1952 by Michel Pistor, a doctor from France. At first, it was used to relieve pain and while it is still sometimes used for this purpose, people also use it for skin rejuvenation nowadays. 

Mesotherapy can treat cellulite, pigmentation, acne scarring, dark circles under the eyes, and skin laxity. Some clinics even use this technique to treat hair loss. 

What Is Microneedling?

Microneedling is a procedure that can improve the skin’s appearance, especially when someone has acne or surgical scars. During the procedure, tiny needles penetrate the skin until they reach the dermis. In return, this can stimulate the production of new elastin and collagen. Sometimes, topical products are also applied to the skin before a microneedling treatment, as it allows them to be absorbed better within the skin cells.

The treatment can treat more severe skin aging signs and scars, making it amazing for individuals who want to look younger.

Who Is Mesotherapy Best for?

Mesotherapy is best for people dealing with fine lines, wrinkles, hyperpigmentation, dehydrated and dull skin, loose skin, and acne scarring. 

Individuals experiencing superficial fat or cellulite on their bodies can also consider mesotherapy treatments in order to make those areas look better. Since the procedure can deal with issues that exist within the skin’s lower layers, it’s a powerful ally against cellulite, saggy skin, dehydrated skin, and other issues. 

Who Is Microneedling Best for?

Microneedling is great for patients who have wrinkles around their neck and eyes, surgical scars on the abdomen, and acne scars on their faces. The treatment can help boost cell exfoliation and regeneration. 

Microneedling may be a better alternative for clients who were thinking about getting dermal fillers or Botox. It’s better at improving skin quality and obtaining more natural results. 

Which Procedure Is More Comfortable?

Mesotherapy is considered more comfortable than microneedling, even though it’s done with a gun. It is done much faster – therefore, it is easier for patients to tolerate it. On top of that, only one needle penetrates the skin, whereas microneedling involves multiple needles at once. 

A topical anesthetic is usually applied on the skin before the microneedling procedure, but this isn’t required for mesotherapy. This goes to show the difference in comfort level between the two procedures. 

How to Choose Between the Two?

It can be quite challenging to choose between mesotherapy and microneedling considering how effective both of them can be when dealing with aging signs and scarring. However, you must pick one based on the problems you are dealing with and how severe they are. 

If you want to improve the texture of your skin, then you can choose any of the two procedures as both of them are effective. On the other hand, if you want to reduce the appearance of fine lines and wrinkles, you should consider microneedling as it offers better results. 

Mesotherapy is a better option when you are dealing with pigmentation issues as the injections have ingredients that are essential for long-term skin health. 

How Often Should the Procedures Be Done?

With mesotherapy, patients will have to go through 4-6 sessions, depending on the issues they are experiencing. Also, each session must be done once every 2-4 weeks. Microneedling must be done every 2-3 months – therefore, you don’t have to keep going to the clinic that often. 

Mesotherapy doesn’t need any downtime though, which makes it ideal if you want to go back to work afterwards. At the same time, microneedling may require 3-5 days of downtime. 


Both mesotherapy and microneedling are outstanding and help with various issues, but the one you should pick depends on what skin problems you are dealing with. One procedure may be better than the other in some cases, so make sure to consider this before choosing a treatment.


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